Research

Chemical probes for biomedical imaging, including Magnetic Resonance and optical imaging. Multifunctional diagnostic and therapeutic agents.

Selected Publications

· Enhui Pan1, Xiao-an Zhang 1, Zhen Huang, Artur Krezel, Min Zhao, Christine E. Tinberg, James McNamara, Stephen J. Lippard,Vesicular Zinc Promotes Presynaptic and Inhibits Postsynaptic Long Term Potentia-tion of Mossyfiber-CA3 Synapse Neuron.2011,Accepted 1 Equal Contributions)

· Subrata Ghosh, Pilhan Kim, Xiao-an Zhang, Andy Yun, Anna Moore, Stephen Lippard, Zdravka Medarova, A Novel Imaging Approach for Early Detection of Prostate Cancer Based on Endogenous Zinc Sensing. Cancer Res.2010,. 70(15), 6119-6127 Highlighted as an Editor’s Choice in Science, 2010, 329, 885

· Taekwan Lee, Xiao-an Zhang, Shanta Dhar, Henryk Faas, Stephen J. Lippard, Alan Jasanoff, In Vivo Imaging with a Cell-Permeable Porphyrin-Based MRI Contrast Agent.Chem. & Bio. 2010, 17, 665-673

· Tatjana Atanasijevic, Xiao-an Zhang, Stephen J. Lippard, and Alan Jasanoff, MRI Sensing Based on the Displacement of Paramagnetic Ions from Chelated Complexes. Inorg. Chem.2010,49(6), 2589-2591

· Xiao-an Zhang, Dugan Hayes, Sarah J. Smith, Simone Friedle, Stephen J. Lippard, New Strategy for Quantifying Biological Zinc by a Modified Zinpyr Fluorescence Sensor. J. Am. Chem. Soc.2008 130(47), 15788-15789 Highlighted in Chem. & Eng. News, 2010, 88(38), 29)

· Xiao-an Zhang, Datong Song, Stephen J. Lippard,A Reversible pH-Dependent Intramolecular Pyridine-Aldehyde Cyclization. J. Org. Chem. 2008, 73(2), 734-737.

· Xiao-an Zhang, Katherine Lovejoy, Alan Jasanoff, Stephen J. Lippard,Water-Soluble Porphyrins as a Dual-Function Molecular Imaging Platform for MRI and Fluorescence Zinc Sensing. Proc. Natl. Acad. Sci. USA,2007, 104(26), 10780-10785

· Xiao-an Zhang, Wolf-D Woggon, From the First Fluorescent Sensor of Pyrovanadate to the Functional Model of Vanadium Haloperoxidase. J. Am. Chem. Soc,2005, 127(41), 14138-14139.

· Xiao-an Zhang, Markus Meuley, Wolf-D Woggon, The First Supramolecular Receptor of Orthovanadate: Towards Mimics of Vanadium Haloperoxidase. J. Inorg. Biochem.,2004, 98(11), 1967-1970.