Research

Research and development of a new generation of biosensors to accelerate the discovery of multi target Alzheimer's disease therapeutics modulating amyloid aggregation and other biomolecular targets such as acetylcholinesterase. Analysis on biosensors to detect biomolecular targets in response to therapeutics using miniaturized, cost-effective and rapid techniques.

Selected Publications

- X. R. Cheng, A. J. Veloso, K. Kerman, Reflection spectroscopy for the determination of Au nanostructure formation on carbon surfaces, Talanta, 2011, in press.

- V. W. S. Hung, K. Kerman, Gold electrodeposition on carbon nanotubes for the enhanced electrochemical detection of homocysteine,Electrochem. Commun., 2011, 13, 328-330.

- V. Dounin, A. Constantinof, H. Schulze, T. T. Bachmann, K. Kerman, Electrochemical detection of interaction between Thioflavin T and acetylcholinesterase, Analyst, 2011, 136, 1234-1238.

- D. Fiorella, X. R. Cheng, T. Chan, K. Kerman, Electrochemical detection of AChE-induced gold nanostructure growth on disposable chips, Electrochem. Commun., 2011, 13, 190-193.

- T. Chan, A. M. Chow, D. Tang, I. R. Brown, Q. Li, S. Wang, K. Kerman,Interaction of baicalein and copper with alpha-synuclein: Electrochemical approach to the Parkinson's Disease,J. Electroanal. Chem.,2010,648, 151-155.

- V. Dounin, A. J. Veloso, H. Schulze, T. T. Bachmann, K. Kerman, Disposable electrochemical  printed gold chips for the analysis of acetylcholinesterase inhibition, Anal. Chim. Acta, 2010, 669, 63-67.

- C. Rambihar, K. Kerman, Magnetic bead-based fluorometric detection of lectin-glycoprotein interactions, Talanta, 2010, 81, 1676-1680.

- H. M. Hiep, K. Kerman, T. Endo, M. Saito, E. Tamiya, Nanostructured biochip for label-free and real-time optical detection of polymerase chain reaction, Anal. Chim. Acta, 2010, 661, 111-116.

- A. J. Veloso, V. W. S. Hung, G. Sindhu, A. Constantinof, K. Kerman, Electrochemical oxidation of benzothiazole dyes for monitoring amyloid formation related to the Alzheimer’s Disease, Anal. Chem.2009, 81, 9410-9415.

- K. Kerman, H.-B. Kraatz, Electrochemical probing of HIV enzymes using ferrocene-conjugated peptides, Analyst 2009, 134, 2400-2404.

- M. Vestergaard, K. Kerman, Analytical tools for detecting amyloid beta oligomerisation and assembly, Curr. Pharm. Anal., 2009, 5, 229-245.

- K. Kerman, H.-B. Kraatz, Electrochemical detection of protein tyrosine kinase-catalysed phosphorylation using gold nanoparticles. Biosens. Bioelectron. 2009, 24, 1484-1489.