James W. Gurd

Professor Emeritus of Biochemistry
Office: (416) 287-7410
Lab: (416) 287-7408
Fax: (416) 287-7676
e-mail: gurd@utsc.utoronto.ca



Research Focus

Effects of stress,  such as ischemia and seizures, on the biochemistry of synapses of the CNS.  Our findings are consistent with the general hypothesis that stress induced changes in the molecular architecture of the synapse may be critically involved in neuropathology.


Research Opportunities

No positions are currently available.


 
   



Recent Publications

  • Young H. Ju, Angelina Guzzo, Mary W. Chiu, Paul Taylor, Michael F. Moran, James W. Gurd, John F. MacDonald, and Beverley A. Orse (2009) Distinct Properties of Murine alpha-5 gamma-Aminobutyric Acid Type A Receptors Revealed by Biochemical Fractionation and Mass Spectroscopy.  Journal of Neuroscience Research 87  1737 - 1747

  • James W Gurd, Salma Rawof, Jeanne Zhen Huo, Crystal Dykstra, Nankie Bissoon, Lucy Teves, M. Christopher Wallace, and John AP Rostas (2008) Ischemia and status epilepitcus result in enhanced phosphorylation of calcium and calmodulin-stimulated protein kinase II on threonine 253. Brain Research 1218 158-65.

  • Shintaro Besshoh, Sheng Chen, Ian R Brown and James W Gurd (2007) Developmental changes in the association of NMDA receptors with lipid rafts. Journal of Neuroscience Research. 85 1876-1883.

  • Guangming Zhang, Warren Ho, Denis G. M. Jugloff, Benjamin P. Jung, Herman H. Cheung, James W. Gurd, M. Christopher Wallace and James H. Eubanks (2007) Isolation and Characterization of LCHN: a Novel Factor Induced by Transient Global Ischemia in the Adult Rat Hippocampus. J Neurochem 101 263-73.

  • Jeanne Zhen Huo, Crystal M. Dykstra and James W. Gurd (2006) Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus. Neurosci. Lett. 401 266-270.

  • Paola V. Migues, Ingo T. Lehmann, Lisa Fluechter, Martin Cammarota, James W. Gurd, Alistair T.R Sim, Phillip W. Dickson, and John A.P. Rostas. (2006) Phosphorylation of CamKII at Thr253 occurs in vivo and enhances binding to isolated post synaptic densities. J. Neurochem. 98 289-299

  • Sheng Chen, Damanpreet Bawa, Shiintaro Besshoh, James W Gurd and Ian R Brown (2005) Association of heat shock proteins and neuronal membrane proteins with lipid rafts from the rat brain. J. Neurosci. Res. 81 522-529

  • Shilpa Vij S.J. Vannucci and James W. Gurd (2005) Differential effects of hypoxia-ischemia on phosphorylation of the NMDA receptor in one and three week old rats. Dev. Neurosci. 27 211 - 219 

  • M. Niimura, R. Moussa, N. Bissoon, C. Ikeda-Douglas, N.W. Milgram and J.W. Gurd (2005) Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus. J.Neurochem. 92 1377-1385.

  • Shintaro Besshoh, Damanpreet Bawa, Lucy Teves, M. Christopher Wallace and James W. Gurd (2005) Increased phosphorylation and redistribution of NMDA receptors between synaptic lipid rafts and postsynaptic densities following transient global ischemia in the rat brain. J. Neurochem. 93 186-194.

  • Arshad M. Khan, Herman H. Cheung, Elizabeth R. Gillard, Jennifer A. Palarca,
    Derek S. Welsbie, James W. Gurd and B. Glenn Stanley (2004) Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions of Src Family Tyrosine Kinases to Feeding Triggered Either by NMDA Injection or by Food Deprivation. J Neurosci. 24 10603 ¨C 10615.

  • Cheung HH, Teves L, Wallace MC and Gurd JW. Inhibition of PKC reduces tyrosine phosphorylation of the NMDA receptor followingtransient global ischemia. J. Neurochem. in press. 86 1441-1449 (2003)

  • Aarts,M, Liu, Y, Liu, L, Besshoh, S, Arundine, M, Gurd, JW, Wang, Y-T, Salter, MW and Tymianski, M. (2002) Treatment of ischemic brain damage by uncoupling NMDA receptor-PSD-95 protein interactions. Science 298: 846-850.

  • Boonstra, R., Takagi, N., Bissoon, N., Vij, S., and Gurd, J.W. (2002) Trapping-induced changes in expression of the
    N-methyl-D-aspartate receptor in the hippocampus of snowshoe hares. J. of Neurosci. Lett. 324 173-176.

  • Gurd, JW, Bissoon, N, Beesley, PW, Nakazawa, T, Yamamoto, T, and Vannucci SJ (2002) Differential effects of hypoxia-ischemia on subunit expression and tyrosine phosphorylation of the NMDA receptor in 7 and 21 day old rats. J. Neurochem. 82:848-856.

  • Moussa, R, Thakur, V, Ikedo-Douglas, C., Milgram, B and Gurd, JW (2001) Seizure activity results in increased tyrosine phosphorylation of the NMDA receptor in the hippocampus. Mol. Brain Res. 95 36-47.

  • Cheung H, Teves L, Wallace MC and Gurd JW (2001) Increased phosphorylation of the NR1 subunit of the NMDA receptor following cerebral ischemia. J. Neurochem. 78 1179-82.

  • Cheung, Herman H. and Gurd, James W. (2001) Tyrosine phosphorylation of the N-methyl-D-aspartate receptor by exogenous and postsyaptic density-associated src-family kinases J. Neurochem. 78 524-34.

  • Lin Pei, R. Lucy Teves, M. Christopher Wallace, and James W. Gurd (2001) Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic RAS-GTPase activating protein, SynGAP. J. Cereb. Blood Flow Metab. 21 955-63.

  • Cheung HH, Takagi N, Teves L, Logan R, Wallace MC, Gurd JW. (2000) Altered association of protein tyrosine kinases with postsynaptic densities after transient cerebral ischemia in the rat brain. J Cereb Blood Flow Metab. 20 505-12 .

  • Takagi, N, Logan, R, Teves, L, Wallace, MC and Gurd JW (2000) Altered interaction between PSD-95 and the NMDA receptor following transient global ischemia. J Neurochem. 74 169-78.

  • Gurd, JW, Bissoon, N, Nguyen, T-H, Lombroso, PJ, Beesley, PW, Rider, CC and Vannucci, SJ (1999) Hypoxia-ischemia in perinatal rat brain induces the formation of a low molecular weight form of the protein tyrosine phosphatase STEP. J. Neurochem. 73 1990-1994.

  • Takagi, N., Bissoon, N., Leves, L., Wallace, M.C. and Gurd, J.W. (1999) The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains. J Cereb Blood Flow Metab. 19 880-888.


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